The purpose of a study published in Arquivos de Gastroenterologia was to evaluate frequency of elevated anti-tissue trasnglutaminse (anti-TTG) in children with constipation after failure to improve during 6 weeks of appropriate treatment of constipation. This cross sectional study recruited 550 children with prolonged constipation, with a mean age of 6.8±2.9 years. The results revealed that the anti-TTG antibody level was 5.8±2.8 unit/mL. Among these pediatric patients, 42 were positive for anti-TTG antibody. Meanwhile, celiac disease was confirmed in 40 cases, on histopathological examination. Hence, the findings indicated that anti-TTG was positive in 7.6% children with chronic constipation who failed to respond after 6 weeks of treatment for their condition.